Welcome to the Levine Lab

Biological systems are interacting composite systems at all scales, from macromolecules to cells to communities. Our lab combines experiments and theory to understand how these collectives coordinate and execute their response to environmental conditions.

Here is a list of some of our recent publications

• H. Teimouri, E. Korkmazhan, J. Stavans, and E. Levine, Sub-cellular mRNA localization modulates the regulation of gene expression by small RNAs in bacteria. (in submission)
• E. Korkmazhan, H. Teimouri, N. Peterman, and E. Levine, The dynamics of translation can determine the spatial organization of membrane-bound proteins and their mRNA. (in submission)
• A. Bitran, W.Y. Chiang, E. Levine, and M. Prentiss, Mechanisms of fast and stringent search in homologous pairing of double-stranded DNA. PLoS Comp Bio (2017).
• N. Peterman and E. Levine, Sort-seq under the hood: implications of design choices on large-scale characterization of sequence-function relations. BMC Genomics 17 206 (2016).
• H.-T Hsu, H.-M.Chen, A. Burger, Z.Y. Yang, K. Zaret, T. Liu, E. Levine, and S.E. Mango, Recruitment of RNA Polymerase II by the pioneer transcription factor PHA-4, Science 348 1372 (2015).
• N. Peterman, A. Lavi-Itzkovitz and E. Levine, Large-scale mapping of sequence-function relations in small regulatory RNAs reveals plasticity and modularity, Nucl. Acids. Res. 42, 12177 (2014).
• B. Obermayer and E. Levine, Inverse Ising inference with correlated samples, New Journal of Physics, 16, 123017 (2014).
• B. Obermayer and E. Levine, Exploring the miRNA regulatory network using evolutionary correlations, PLoS Comput Biol 10, e1003860 (2014).
• A. Lavi-Itzkovitz, D. Jost, and E. Levine, Quantitative Effect of Target Translation on Small RNA Efficacy Reveals a Novel Mode of Interaction, Nucl. Acids. Res. 42, 12200 (2014).
• D. Jost, A. Nowojewski, and E. Levine, Regulating the many to benefit the few: role of weak small RNA targets. Biophys. J. 104, 1773–1782. (2013)
• H. Toledano, C. D’Alterio, E. Levine, and D.L. Jones. The let-7-Imp axis regulates ageing of the Drosophila testis stem-cell niche. Nature 485(7400):605-10 (2012).
• E. Levine, “srRNAs”, in Encyclopedia of Genetics, 2nd Ed. (Elsevir, Oxford 2012).

• L. E. Lee, K. S Lee, J. Irazoquoi, and E. Levine, High-order organization of the C. elegans host response links glutamatergic neurotransmission and host tolerance of infection.(in submission)
• A. Nowojewski, L. Lee and E. Levine, Pathogen avoidance by Caenorhabditis elegans is a pheromone-mediated collective behavior. (in submission)
• K.S. Lee, L.E. Lee, and E. Levine, HandKAchip - Hands-free killing assay on a chip. Sci Rep 6 35862 (2016).

• K. S. Lee, D. Biron, and E. Levine, The role of serotonin in the regulation of feeding revealed through mapping to a Brownian-like motion on the feeding-rate axis. (in submission)
• R. Kopito, K. Watkins and E. Levine, Heat shock response of the insulin/IGF-1 pathway integrates local and systemic signals.
• K.S. Lee, S. Iwanir, R. Kopito, D. Biron and E. Levine, Regulation of food uptake by serotonin-dependent balance between two modes of feeding. Nature Comm 8, 14221 (2017).
• M. Scholz, D.J. Lynch, K.S Lee, E. Levine, D. Biron, A scalable method for automatically measuring pharyngeal pumping in C. elegans. J Neurosci Methods. S0165-0270 (2016).
• Iwanir, A.S Brown A. Kazakov, K.S. Lee, A. Zaslaver, E. Levine and D. Biron, Serotonin promotes exploitation in complex environments by accelerating decision-making. BMC Biology 14 9 (2016).
• I. Neagu and E. Levine, A Primer on Quantitative Modeling, Methods Mol Biol. 1327 241 (2015).
• R. Kopito and E. Levine, Durable spatiotemporal surveillance of Caenorhabditis elegans response to environmental cues, Lab on Chip 21, 14 (2014).